What is the morbidity associated with complex regional pain syndrome (CRPS)?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Despite treatment, many patients are left with varying degrees of chronic pain, trophic changes, and disability. Pain is the most important factor leading to disability. Some have suggested that the aggressive treatment of pain in an acute setting could reduce the incidence of CRPS type I; however, further studies are needed to support this contention. Remissions followed by relapses have also been described. The frequency of the HLA-DQ1 antigen appears to be higher in patients with CRPS than in controls, and HLA-DR13 is associated with progression towards multifocal or generalized dystonia. [52, 53] Recently, a new HLA I locus was detected that may predict the spontaneous onset of CRPS. [54]

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