What is the incidence of complex regional pain syndrome (CRPS) in the US?

Updated: Jun 20, 2018
  • Author: Gaurav Gupta, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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A population-based study by Sandroni et al showed an incidence of approximately 5.5 per 100,000 person-years at risk and a prevalence of about 21 per 100,000 for CRPS type I. [47] The same study showed an incidence of 0.8 per 100,000 and a prevalence of about 4 per 100,000 for CRPS type II. [47, 14] Therefore, the incidence of CRPS type I is higher than that of CRPS type II. [47, 14] The reported incidence of CRPS type I is 1-2% after various fractures [14] , while that of CRPS type II approximates 1-5% after peripheral nerve injury [14, 48] . The incidence of CRPS is 12% after a brain injury [49] and 5% after a myocardial infarction [50] .

A study from the Netherlands showed a total incidence of CRPS of approximately four times higher than the incidence rate observed in the only other population-based study, performed in Olmsted County, USA. [51] The estimated overall incidence rate of CRPS was 26.2 per 100,000 person years with females affected at least three times more often than males. The highest incidence occurred in females aged 61-70 years. The upper extremity was affected more frequently than the lower extremity and a fracture was the most common precipitating event (44%). [51]

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