Which medications in the drug class Tricyclic Antidepressants are used in the treatment of Trigeminal Neuralgia?

Updated: Jul 11, 2019
  • Author: Manish K Singh, MD; Chief Editor: Robert A Egan, MD  more...
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Tricyclic Antidepressants

Tricyclic antidepressants are a complex group of drugs that have central and peripheral anticholinergic effects, as well as sedative effects. They have central effects on pain transmission and block the active reuptake of norepinephrine and serotonin.


A minority of patients might respond to amitriptyline. Anticholinergic adverse effects are the limitation.

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