Which tricyclic antidepressants (TCAs) are used in the treatment of low back pain (LBP) and sciatica?

Updated: Aug 22, 2018
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Venlafaxine is a structurally novel antidepressant shown to produce strong uptake inhibition with both serotonin and norepinephrine and have anesthetic properties similar to the TCAs. [107] An uncontrolled case series reported that venlafaxine provided pain relief in a variety of neuropathic pain disorders. [107]

Recent studies have shown duloxetine (Cymbalta) to provide significant pain relief compared with placebo for chronic musculoskeletal pain, including low back pain and pain caused by osteoarthritis. In November 2010, the US Food and Drug Administration (FDA) approved duloxetine for treatment of chronic musculoskeletal pain. [108, 109, 110, 111]

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