What is the role of drug treatment for low back pain (LBP) and sciatica?

Updated: Aug 22, 2018
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Rational pharmacology for the treatment of spinal pain is aimed at causative peripheral and central pain generators, determined by the types of pain under therapeutic scrutiny (eg, neuropathic and/or nociceptive), and modified additionally to deal with the evolving neurochemical and psychological factors that arise with chronicity. In general, the published research for evaluating the efficacy of medication in treating neck and back pain has demonstrated faulty methodology and inadequate patient/subject description. [55] However, medication continues to be used as adjunct to other measures because of anecdotal reports, perceived standards of care, and some supportive clinical research.

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