What is the role of algogenic substances in the pathophysiology of low back pain (LBP)?

Updated: Aug 22, 2018
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Algogenic substances that are typically involved in tissue damage and that can induce peripheral transduction include potassium, serotonin, bradykinin, histamine, prostaglandins, leukotrienes, and SP. Transduction leads to transmission, which is the conduction of afferent pain signals to the DRG and dorsal horn of the spinal cord. The DRG contains the cell bodies of various primary afferent nociceptors, including for the neuropeptides SP, VIP, and CGRP. The DRG is mechanically sensitive and capable of independent pain transduction, transmission, and modulation. Transduction is the process whereby noxious afferent stimuli are converted from chemical to electrical messages in the spinal cord that travel cephalad to the brainstem, thalamus, and cerebral cortex.

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