What is the role of somatostatin in the pathogenesis of low back pain (LBP) and sciatica?

Updated: Aug 22, 2018
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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Somatostatin is another neuropeptide found in high concentrations in the dorsal gray matter of the spinal cord. Somatostatin is released from the DRG after noxious thermal stimulation and likely plays a role in pain transmission and in producing neurogenic inflammation. Therefore, the release of neuropeptides like SP, VIP, and CGRP may occur in response to noxious biochemical forces and environmental factors (eg, biomechanical stress, microtrauma, vibration), stimulating the synthesis of inflammatory agents (eg, cytokines, prostaglandin E2) and degradative enzymes (eg, proteases, collagenase). These factors cause progressive deterioration of the motion segment structures, especially the intervertebral disk.

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