What is the role of alkalinizing agents (sodium bicarbonate) in the performance of therapeutic injections for pain management?

Updated: Jun 19, 2018
  • Author: Anthony H Wheeler, MD; Chief Editor: Meda Raghavendra (Raghu), MD  more...
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Alkalinizing agents are thought to facilitate the onset of action and prolong neural blockade when combined with LAs; however, recent double-blind studies in humans have failed to substantiate that this actually occurs. Nevertheless, addition of sodium bicarbonate to bupivacaine still is advocated to produce faster onset of epidural blockade with longer duration.

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