What is the role of vitamin C in the treatment of postherpetic neuralgia (PHN)?

Updated: Mar 06, 2018
  • Author: W Alvin McElveen, MD; Chief Editor: Robert A Egan, MD  more...
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Answer

Chen et al found vitamin C plasma concentrations are lower in 38 patients with postherpetic neuralgia compared with 39 healthy volunteers (P< .001). In this study, restoration of vitamin C concentrations decreased spontaneous pain (but not brush-evoked pain) by 3.1 on a numeric pain scale in the postherpetic neuralgia group compared with placebo treatment (P< 0.001). The authors concluded that vitamin C status is a component in postherpetic neuralgia and is a component involved in spontaneous pain relief. [12]


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