What is the role of genetic testing in the workup of migraine variants (equivalents)?

Updated: Oct 16, 2019
  • Author: Rima M Dafer, MD, MPH, FAHA; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Answer

Genetic testing for familial hemiplegic migraine (FHM) can be done by using polymerase chain reaction (PCR) evaluation to detect point mutations in CACNA1A and ATP1A2; DNA sequencing is also available. Genetic testing may also be performed for other conditions associated with migraine, such as cerebral autosomal dominant arteriopathy and subcortical infarcts and leukoencephalopathy (CADASIL), an autosomal dominant disorder in which patients may present with migraine, multiple subcortical strokes, and dementia in early adulthood.


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