What is sporadic hemiplegic migraine (SHM)?

Updated: Oct 16, 2019
  • Author: Rima M Dafer, MD, MPH, FAHA; Chief Editor: Helmi L Lutsep, MD  more...
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SHM is defined as migraine attacks associated with motor weakness in the absence of a family history of similar attacks. [36, 37] Cases of SHM have also been linked to the CACNA1A and ATP1A2 genes.

The diagnosis of FHM is usually confirmed with repeated stereotyped reversible episodes, particularly in the presence of a positive family history of similar attacks. However, the absence of first- and or second-degree relatives with similar disorder raises suspicion of SHM. [38] The differential diagnosis for SHM includes focal seizures with postictal paralysis, mitochondrial cytopathies, intracranial hemorrhage, mass, infection, and cerebral infarction. [39]

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