Which medications in the drug class Analgesics, Other Combos are used in the treatment of Migraine Headache?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Analgesics, Other Combos

A combination drug containing isometheptene, dichloralphenazone, and acetaminophen is FDA approved for the relief of migraines and tension headaches.

Isometheptene, dichloralphenazone, and acetaminophen (Midrin, Epidrin)

This combination drug has sympathomimetic properties. Isometheptene, in particular, dilates cranial and cerebral arterioles, causing a reduction in the stimuli that lead to vascular headaches. Dichloralphenazone has sedative and analgesic properties. Acetaminophen inhibits the synthesis of prostaglandins in the central nervous system (CNS) and blocks pain impulses generated in the periphery.

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