Which medications in the drug class Antipsychotics, Phenothiazine are used in the treatment of Migraine Headache?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Antipsychotics, Phenothiazine

Chlorpromazine can be used as monotherapy for acute migraine headaches.

Chlorpromazine (Thorazine)

The mechanisms of chlorpromazine include blocking postsynaptic mesolimbic dopamine receptors, anticholinergic effects, and depression of the reticular activating system. The drug blocks alpha-adrenergic receptors and depresses the release of hypophyseal and hypothalamic hormones. As a rule, dopamine antagonists are avoided in patients with traumatic brain injury.

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