Which medications in the drug class Antihistamines, 1st Generation are used in the treatment of Migraine Headache?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Antihistamines, 1st Generation

Agents in this class with potent serotonin antagonist activity have been reported to be effective in the treatment of migraine.

Promethazine (Phenergan, Phenadoz, Promethagan)

Promethazine is a phenothiazine derivative that possesses antihistaminic, sedative, anti ̶ motion-sickness, antiemetic, and anticholinergic effects. It is commonly used in children older than 2 years.

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