Which medications in the drug class Antidepressants, SSRIs are used in the treatment of Migraine Headache?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Antidepressants, SSRIs

SSRIs have limited efficacy for migraine prophylaxis in adults. Due to a lack of clinical studies, they are not recommended for this purpose in children.

Paroxetine (Paxil, Paxil CR, Pexeva, Brisdelle)

Paroxetine is an atypical, nontricyclic antidepressant with potent, specific inhibition of 5-HT uptake inhibition and fewer anticholinergic and cardiovascular adverse effects than tricyclic antidepressants have.

Fluoxetine (Prozac, Prozac Weekly, Sarafem)

Fluoxetine is a second-line agent for patients with chronic migraines. It is an atypical, nontricyclic antidepressant with potent, specific inhibition of 5-HT uptake and with fewer anticholinergic and cardiovascular side effects than tricyclic antidepressants have.

Sertraline (Zoloft)

Sertraline is an atypical, nontricyclic antidepressant with potent, specific inhibition of 5-HT uptake and fewer anticholinergic and cardiovascular adverse effects than tricyclic antidepressants have.


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