Which medications in the drug class CGRP Monoclonal Antibodies are used in the treatment of Migraine Headache?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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CGRP Monoclonal Antibodies

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and is a key neuropeptide that is central to migraine pathophysiology.

Erenumab (Aimovig)

Human monoclonal antibody. Binds to the calcitonin gene-related peptide (CGRP) receptor, which is thought to be causally involved in migraine pathophysiology. It is indicated for preventive treatment of migraines in adults.

Fremanezumab (Ajovy, fremanezumab-vfrm)

Human monoclonal antibody against human calcitonin gene-related peptide (CGRP), which may be causally involved in the pathophysiology of migraines. Fremanezumab in indicated for migraine prophylaxis.

Galcanezumab (Emgality, galcanezumab-gnlm)

Monoclonal antibody that targets CGRP. Inhibition of CGRP interrupts migraine pathway. It is indicated for preventive treatment of migraine.

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