What is the effectiveness of melatonin as a prophylactic treatment for migraine headaches?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Melatonin has also been used for migraine prevention. Alstadhaug et al conducted a randomized, controlled, 8-week trial of prolonged-release melatonin (2 mg 1 hour before bedtime) in adult patients experiencing 2-7 migraine attacks per month. Although the investigators found that in the melatonin group the average attack frequency fell from 4.2 to 2.8 per month, this result was not significantly superior statistically to the reduction seen with placebo. [128]

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