What is the effectiveness of coenzyme Q10 (CoQ10) as a prophylactic treatment for migraine headaches?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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A randomized, controlled trial of coenzyme Q10 (CoQ10) documented that CoQ10 is effective and well tolerated for migraine prophylaxis. [133] Results of a trial in children and adolescents suggested that prophylaxis with CoQ10 may lead to earlier improvement in headache severity than does placebo-based prophylaxis, but the trial found no long-term difference in headache outcomes between the CoQ10 and placebo groups. [134]

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