What medications are being investigated as possible treatments for acute migraine headaches?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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The pipeline of future compounds for the treatment of acute migraine headaches also includes the following medications:

  • Transient receptor potential vanilloid type 1 antagonists

  • Prostaglandin E receptor 4 receptor antagonists

  • Serotonin 5HT1(F) receptor agonists

  • Nitric oxide synthase inhibitors

The immediate future of preventive treatment for migraine headaches will likely involve glutamate N-methyl-D-aspartic acid (NMDA) receptor antagonists and gap-junction blockers. [148]

It is worth mentioning here that so far there is insufficient evidence to support the use of intranasal lidocaine in acute management of primary headaches and requires further research. [149]

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