What is the role of tonabersat in the treatment of migraine headache?

Updated: Oct 01, 2021
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Tonabersat is a novel benzopyran compound that markedly reduces cortical spreading depression (CSD) and CSD-associated events by inhibiting gap-junction communication between neurons and satellite glial cells in the trigeminal ganglion. [155] In a randomized, double-blind, placebo-controlled crossover trial, preventive therapy with tonabersat reduced the frequency of aura attacks with or without headache but had no efficacy on non-aura attacks. [15]

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