What is the role of naproxen sodium in the management of migraine headache?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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The NSAID naproxen sodium has also been used for prophylaxis. In controlled clinical trials, naproxen sodium demonstrated better efficacy than placebo and similar efficacy to propranolol. However, this agent should be reserved for short-term use, such as for menstrual migraines. [107] Tolfenamic acid has also been tried for migraine prophylaxis, but its clinical efficacy is not as good as that of beta blockers, valproate, or methysergide.

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