What is the genetic cause of familial hemiplegic migraine (FHM) type 2?

Updated: Oct 21, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

FHM type 2 occurs in patients who also have a seizure disorder. This condition has been attributed to mutations in the ATP1A2 gene, located on 1q21q23, which encodes a sodium/potassium pump. [36, 37] However, the Danish study found mutations in ATP1A2 in only 7% of patients with a clinical diagnosis of FHM. [35]


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