Which medications in the drug class Neurologics, Other are used in the treatment of Cluster Headache?

Updated: Jun 07, 2019
  • Author: Michelle Blanda, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

Neurologics, Other

Triptans may reduce the inflammation associated with migraine headaches.

Zolmitriptan (Zomig, Zomig-ZMT, Zomig Nasal Spray)

As a selective agonist of 5-hydroxytryptamine-1 (5-HT1) receptors in cranial arteries, zolmitriptan causes vasoconstriction and reduces the inflammation associated with antidromic neuronal transmission in CH. It can reduce the severity of headache within 15 minutes of subcutaneous injection. The intranasal form is now available in the United States, offering an attractive alternative to self-injection.

Naratriptan (Amerge)

As a selective agonist of 5-HT1 receptors in cranial arteries, naratriptan causes vasoconstriction and reduces the inflammation associated with antidromic neuronal transmission in CH. It can reduce the severity of headache within 15 minutes of subcutaneous injection.

Sumatriptan succinate (Imitrex, Alsuma, Sumavel DosePro)

As a selective agonist of 5-HT1 receptors in cranial arteries, sumatriptan causes vasoconstriction and reduces the inflammation associated with antidromic neuronal transmission in CH. It can reduce the severity of headache within 15 minutes of subcutaneous injection. The intranasal form is now available in the United States, offering an attractive alternative to self-injection.

Rizatriptan (Maxalt, Maxalt-MLT)

Rizatriptan is a selective agonist for 5-HT1 receptors in cranial arteries and suppresses the inflammation associated with migraine headaches.

Almotriptan (Axert)

Almotriptan is a selective 5-HT1B/1D receptor agonist used to treat acute migraine. It results in cranial vessel constriction, inhibition of neuropeptide release, and reduced pain transmission in trigeminal pathways.

Frovatriptan (Frova)

Frovatriptan is used to treat acute migraine. It is a selective 5-HT1B/1D receptor agonist with a long half-life (24 hours) and a low headache recurrence rate within 24 hours after taking the drug. It results in cranial vessel constriction, inhibition of neuropeptide release, and reduced pain transmission in trigeminal pathways. It has unique characteristics and benefits in the acute treatment of migraine.

Eletriptan (Relpax)

Eletriptan is a selective serotonin agonist that specifically acts at 5-HT1B/1D/1F receptors on intracranial blood vessels and sensory nerve endings to relieve pain associated with acute headaches.


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