Which medications in the drug class Anesthetics, Topical are used in the treatment of Cluster Headache?

Updated: Jun 07, 2019
  • Author: Michelle Blanda, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Anesthetics, Topical

Local anesthetics stabilize the neuronal membrane so that the neuron is less permeable to ions. This prevents initiation and transmission of nerve impulses, thereby producing local anesthesia.

Lidocaine 4%, (Xylocaine)

Lidocaine blocks conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, which results in inhibition of depolarization and blockade of conduction. Intranasal administration of lidocaine drops is an experimental abortive therapy for CH.

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