Which medications in the drug class Analgesics, Topical are used in the treatment of Cluster Headache?

Updated: Jun 07, 2019
  • Author: Michelle Blanda, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Analgesics, Topical

The short-lived and unpredictable character of CH precludes the effective use of oral narcotics or analgesics. Despite their lack of efficacy, these substances are abused by some CH sufferers.

Narcotics are not recommended in aborting cluster headaches.

Capsaicin (Capzasin-P)

Intranasal capsaicin has been successfully tested in clinical trials. This substance, derived from chili peppers, induces release of substance P, the principal chemomediator of pain impulses from the periphery to the CNS. After repeated applications, capsaicin depletes the neuron of substance P and prevents reaccumulation.

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