Which medications in the drug class Psychiatry Agents, Other are used in the treatment of Cluster Headache?

Updated: Jun 07, 2019
  • Author: Michelle Blanda, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Psychiatry Agents, Other

Lithium’s mechanism of action in CH is unclear, though preliminary evidence suggests that it may interfere with substance P and vasoactive intestinal peptide (VIP)-induced arterial relaxation.

Lithium carbonate (Lithobid)

Variable responses notwithstanding, lithium is still a recommended first-line agent in CH. The narrow therapeutic window necessitates close monitoring of levels and adverse effects. A plasma lithium level of 0.6-1.2 mEq/L measured at steady state 12 hours after the last dose (ie, just before the next dose) is usually sought, but optimal plasma levels for prevention of CH are not established. It is thought to be effective against CH at serum concentrations lower than those required in bipolar disorder (0.3-0.8 mEq/L).

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