Which medications in the drug class Anticonvulsants are used in the treatment of Cluster Headache?

Updated: Jun 07, 2019
  • Author: Michelle Blanda, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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The mechanism of action by which anticonvulsants prevent CH is unclear; it may involve regulation of central sensitization.

Divalproex sodium (Depakote, Depakote ER)

Few adequate studies of divalproex are available, and results have been mixed.

Topiramate (Topamax)

Topiramate has been effective for prophylaxis of CH in several small prospective studies. Its exact mechanism of action in this setting is unknown.

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