Which medications in the drug class Carbonic Anhydrase Inhibitors are used in the treatment of Chronic Paroxysmal Hemicrania?

Updated: Jun 12, 2019
  • Author: Monica Saini, MD, MBBS; more...
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Carbonic Anhydrase Inhibitors

These agents may be used to provide relief in patients with CPH.

Acetazolamide (Diamox)

Acetazolamide is a carbonic anhydrase inhibitor that blocks HCO3 reabsorption in the proximal renal tubules. It causes increased renal excretion of sodium versus chloride, causing a net increase in serum chloride. Acetazolamide is also a diuretic and, therefore, may help decrease extracellular fluid (ECF) volume that frequently accompanies chloride-resistant metabolic alkalosis. Acetazolamide may provide relief in patients experiencing CPH.

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