What is the pathophysiology of peroneal mononeuropathy?

Updated: Jun 08, 2018
  • Author: Shaheen E Lakhan, MD, PhD, MS, MEd; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Compression and entrapment neuropathies are predominantly demyelinating.

  • Myelin loss results in slowing of the nerve conduction through the area involved.

  • When acute compression occurs, this may result in a conduction block. When the compression is more chronic, only slowing across the involved segment may be seen.

  • When compression is severe, ischemic changes occur that cause secondary axonal damage.

  • Pure demyelinating lesions typically have a better capacity to recover.


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