Which findings on EEG are characteristic of pyridoxine-responsive seizures?

Updated: Oct 03, 2019
  • Author: Rosalia C Silvestri-Hobson, MD; Chief Editor: Selim R Benbadis, MD  more...
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In addition to neonatal seizures and reported infantile spasms from Japan, the phenotypic presentation for pyridoxine-responsive seizures includes epileptic encephalopathy of infancy and childhood and should be confirmed by pyridoxine challenge during a therapeutic EEG test. Normalization of follow-up EEGs after seizures response to pyridoxine therapy is the rule. [22] A report by Teune suggests that IV pyridoxine affects EEG background activity with reduction in amplitude and total power in infants younger than age 1 year with therapy-resistant seizures as a nonspecific effect. [23]

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