What is the role of somatosensory evoked potentials (SEPs) in the evaluation of multiple sclerosis?

Updated: Aug 20, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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SEPs of the upper extremities are abnormal in about 60% of all patients with MS (definite, probable, and possible) and in about 40% of patients with asymptomatic MS. SEPs of the lower extremities have a higher frequency of abnormality, presumably since longer axons are more likely to have an area of demyelination. In clinical practice, SEPs of both the upper and lower extremities usually are performed. The change most frequently seen in MS is prolongation of central latencies. MRI has largely supplanted SEP testing in MS.

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