What is the role of motor evoked potentials (MEPs) in the treatment of Parkinson's disease?

Updated: Aug 20, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
  • Print
Answer

Answer

Basic research findings in Parkinson disease support a decrease of the excitatory drive from the thalamus, which projects to the cortex in this disorder, and an enhanced cortical excitability.

Rapid (5Hz) repetitive TMS (rTMS) over the dominant hemisphere has been reported to shorten reaction and movement times in Parkinson disease. Some have reported improvement that lasted 20 minutes after rTMS. Other groups have reported negative results. The use of rTMS probably will be limited to electrophysiologic studies of cortical excitability in Parkinson disease; its therapeutic use remains anecdotal.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!