What is the role of the motor cortex in motor evoked potentials (MEPs)?

Updated: Aug 20, 2019
  • Author: Jasvinder Chawla, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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The main motor cortical area is located on the anterior wall of the central sulcus and the adjacent portion of the precentral gyrus. This area corresponds to area 4 of Brodmann. It is rich in pyramidal neurons, which provide the anatomical substrates for the motor output function of area 4.

Electrical stimuli over area 4 produce activation of contralateral muscles; the face, mouth, and hand muscles occupy about two thirds of the primary motor area. The size of the cortical representation of muscles is less a function of the muscle mass than of precision of the muscle movements. Secondary and tertiary areas of motor function can be mapped roughly around the primary motor cortex.

The primary motor cortex contributes more fibers to the corticospinal tract than any other region. Numerous observations support contributions from several other areas, including the frontal and parietal cortices. Ipsilateral projections are far less numerous than contralateral ones, being estimated to make up 1.8-5.9% of corticospinal connections.

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