What EEG findings are characteristic of Parkinson disease (PD)?

Updated: Oct 09, 2019
  • Author: Eli S Neiman, DO, FACN; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Answer

The EEG is frequently normal in Parkinson disease (PD). In advanced cases, however, marked slowing is noted. Sleep may be markedly abnormal with frequent awakenings, prolonged sleep latency, reduced REM sleep, periodic leg movements and increased frequency of REM behavioral disorder.

Wszolek et al studied patients with rapidly progressive familial parkinsonism and dementia with pallidopontonigral degeneration (PPND). [29] The patients had PPND linked to chromosome 17q21-22; 11 EEGs of 9 patients were studied. EEGs revealed normal findings early in the disease and diffuse slowing that became more prominent with disease progression.

Serizawa et al, using QEEG to compare PD patients with age-adjusted controls, also found diffuse slowing in the patients with PD. [30] Electromyography (EMG) and nerve conduction studies (NCSs) showed no abnormalities. Visual evoked potentials (VEPs) and sensory evoked potentials (SEPs) were normal. The clinical neurophysiologic study findings were consistent with a cortical and subcortical degenerative process.

With clinical deterioration, progressive decline is seen in the mean parietal frequency and background rhythms. Theta and theta-delta mixture may be recorded bilaterally in the posterior head regions. After stereotactic surgery, focal theta or delta slowing may be observed.


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