What is the role of somatosensory evoked potentials (SEPs) in the workup of vitamin B-12 deficiency?

Updated: Oct 25, 2019
  • Author: Andrew B Evans, MD; Chief Editor: Selim R Benbadis, MD  more...
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Both upper- and lower-limb SEPs have been found to be abnormal in patients with vitamin B-12 deficiency, often showing either no components or only the peripheral EP peak. Puri et al reported that serum vitamin B-12 level correlated well with the latencies of P37 and sural SNAP. [75] On treatment, normalization of P100, MRI signal, and N20 and partial recovery of P37 latencies were seen at 6 months, 9 months, and 1 year, respectively. [75]

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