Which systems are excessively activated in the pathogenesis of chronic subdural hematoma (SDH)?

Updated: Jul 26, 2018
  • Author: Richard J Meagher, MD; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

In 1989, Kawakami discovered that the coagulation and fibrinolysis systems were both excessively activated in chronic subdural hematoma. [8] This results in defective clot formation and recurrent hemorrhage. Katano et al reported that elevated concentrations of tissue plasminogen activator are found in some chronic subdural hematomas, and indicate a relatively high probability of recurrence. [9]


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