What is the role of estrogen in the treatment of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Estrogen epidemiologic data suggested that postmenopausal women taking estrogen had a decreased risk of developing AD. However, a clinical trial testing this hypothesis among women older than 65 years who had a family history of AD was halted because the women treated with estrogen appeared to have an increased risk for dementia. Data suggest that estrogen therapy may have a protective role if started in younger women at the onset of menopause. Present evidence does not support the use of estrogen for the treatment or prevention of AD.

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