What is the role of drugs to decrease Abeta in the treatment of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Answer

Drugs that decrease the accumulation of amyloid beta (Abeta) in the brain have been tried in persons with mild AD without DS, but even though the tolerance was good and there was a reduction in the amount of Abeta 42 in the cerebrospinal fluid (CSF), there was no significant clinical impact. [128] Trials involving active immunization of patients with Abeta were halted because 7% of patients developed encephalitis. How effective immunization was in slowing progression in this trial is controversial.


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