What is the role of memantine in the treatment of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Memantine is the only drug of this group approved for use in AD. A 2009 Cochrane review found no studies for inclusion. [125] Subsequently, a randomized, double-blind, placebo-controlled study of memantine for dementia in DS patients older than 40 years found no evidence of efficacy. [126] This was also confirmed in a 2015 cochrane review. [124]  

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