What is the role of EEG in the workup of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Patients with DS have a high baseline prevalence of seizures, and the prevalence increases further as patients develop AD. It is prudent to obtain an electroencephalogram (EEG) in the baseline evaluation of a patient with DS and dementia. However, this test does not help to diagnose dementia, since no specific patterns correlate with dementia. There is deterioration in the background activities as the dementia progresses, with increased slowing that is seen in the whole brain and loss of normal structures. In addition, at one point in the disease, the EEG may show epileptic form activity.

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