What is the role of genetic testing in the workup of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Answer

Telomeres are sequencing of DNA at the end of the chromosome that get shorter with the division of the cell and, indirectly, are a measure of cell aging. Shortening of the telmore has been reported in AD patients without DS. Similar association has been reported in persons with DS and dementia. [83] Telomere shortening may be a biological marker of dementia status, but more research is needed.


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