What is the role of lumbar puncture in the workup of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Lumbar puncture is indicated in the evaluation of dementia without DS when conditions that could be diagnosed by examination of cerebrospinal fluid (CSF), such as fungal meningitis are reasonable diagnostic possibilities. Most of the time, such conditions are so unlikely that lumbar puncture is rarely performed as part of routine medical care in the evaluation of dementia. These same criteria should be used when lumbar puncture is considered in patients with dementia and DS. (see Biomarkers).

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