What other causes of dementia should be included in the differential diagnosis of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Answer

Other problems to be considered include the following:

  • Depression and other psychiatric disorders

  • Dementia in Parkinson disease

  • Dementia in progressive supranuclear palsy

  • Multi-infarct dementia

Imaging studies are useful for excluding other causes of dementia, including subdural collections, tumors, and multiple infarcts. Once the diagnosis is established, repeat imaging is indicated when the course of progression is not consistent with AD (eg, when very rapid deterioration is observed). The dementia screening tests marketed to consumers are of questionable usefulness in persons without DS and of no value in patients with DS. [77]


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