How is mild cognitive impairment differentiated from early-stage Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
  • Print


The term mild cognitive impairment (MCI) is used to describe a state of cognitive decline representing a transition between normal cognition and dementia. This state is characterized by impairment in memory and other cognitive functions as demonstrated by standardized neuropsychological tests. A substantial percentage of patients with the amnestic form of MCI progress to AD within 4 years of diagnosis. The lack of adequate normative data for memory in DS in different age groups makes the concept of MCI impossible to operationalize in individuals with DS.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!