What is the association between epileptic seizures and Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Answer

In the author's research, epileptic seizures of the tonic-clonic type have been described. These occur approximately 2.4 years (range, 7 mo to 6.1 y) after the disease presents. Usually, generalized tonic-clonic seizures are infrequent; if present, they can typically be controlled with antiepileptic medication.

Myoclonic seizures occur more frequently than tonic-clonic seizures. The myoclonus may be stimulus-sensitive and can be induced by light or a simple touch. In the advanced stages, myoclonic seizures may be constantly present. This has been described as late-onset myoclonic epilepsy in DS [72] or senile myoclonic epilepsy. [73]


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