What are the sexual predilections of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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In patients without DS, the influence of sex on the incidence and prevalence of AD remains controversial. Some, but not all, studies suggest that the prevalence is higher in women than in men. Few studies have evaluated the influence of sex on AD in patients with DS, and the results have been contradictory. [46]  

There are some indications that the onset of dementia is related to early menopause in women with DS. This might suggest some role for estrogen in the development of AD in women with DS; however, this possibility is not a sufficient reason to suggest hormone therapy in this population. [20, 64, 65] There is also an indication that men with DS have an earlier onset of AD than women with DS do [5] ; this suggests that other associated hormonal changes might also be important. 

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