What is the role of Tau protein in the pathophysiology of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Answer

This intracellular protein, which is found in the nuerofibrillary tangles (NFT), is also regulated by genes in chromosome 21. The overexpression of these genes may explain the increase in tau protein found in the cortex of persons with DS. [37]


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