What is the role of estrogen in the pathophysiology of Alzheimer disease (AD) in Down syndrome (DS)?

Updated: Nov 13, 2019
  • Author: Norberto Alvarez, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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AD seems to occur more frequently in women than in men. However, this issue is not well studied in persons with DS, but some studies indeed suggest that this might also be the case in females with DS, suggesting that reductions in estrogen following menopause can contribute to the cascade of pathological processes leading to AD. [30]

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