What is semantic dementia in frontotemporal dementia (FTD)?

Updated: Jun 14, 2018
  • Author: Howard S Kirshner, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Semantic dementia is a fluent aphasia with impaired naming and impaired knowledge of word meanings, such that even single word comprehension becomes affected. Patients often have surface dyslexia in reading, spared repetition and motor speech, and, sometimes, poor object and person knowledge. Semantic dementia was first named by Snowden and colleagues [56] and was later defined by Hodges and his group in the United Kingdom. [57, 58] The pathology can be variable, including mostly FTLD-U cases, many with progranulin mutations, but a few have been associated with Alzheimer disease.

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