What is progressive nonfluent aphasia in frontotemporal dementia (FTD)?

Updated: Jun 14, 2018
  • Author: Howard S Kirshner, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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In progressive nonfluent aphasia, speech is effortful and halting, with phoneme or speech sound errors; language production is simplified and agrammatic; and there is usually sparing of word comprehension and object knowledge, but often with impaired comprehension of syntax. This is, in other words, a Broca-like aphasia, often associated with dysarthria and with hesitant, groping speech and difficulty producing phonemes. These cases almost always have a non-Alzheimer pathology and most commonly a MAPT mutation or tau-based disorder. Rohrer and colleagues [55] reported that agrammatism and apraxia of speech were specifically useful in predicting the presence of a tau mutation and progressive nonfluent aphasia.

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